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The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid-Coated Gold Nanorods 期刊论文

编号：

fd3ee4f7-812d-49f8-a6c6-277a9d3252dc
作者：

Pan, Su(潘肃)#^[1]Xing, Hongcun#^[2]Fu, Xuqi^[2];Yu, Hongmei(遇红梅)^[3]Yang, Zhaogang^[4];Yang, Yudan(杨宇丹)*^[3]Sun, Wei*^[5]
语种：

英文
期刊：

DOSE-RESPONSE ISSN：1559-3258 2018 年 16 卷 3 期 ; AUG 29
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关键词：

osteosarcoma photothermal therapy metal nanostructures apoptosis time-dose dependent
摘要：

Background: Polyacrylic acid (PAA)-coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected.
Methods: It was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior efficiency of hyperthermia therapy for MG63 human osteosarcoma cell.
Results: The mechanism of photothermal therapy of GNRs@PAA was explored, and it was proved that damaged cell membrane and DNA integration caused cell apoptosis and death, and the cell apoptosis rate had been obviously promoted by in vitro photothermal therapy which exhibited time-dose dependence.
Conclusion: The results demonstrated that the GNRs@PAA could be a promising candidate for phototherapeutic applications in human osteosarcoma.
推荐引用方式
GB/T 7714：

Pan Su,Xing Hongcun,Fu Xuqi, et al. The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid-Coated Gold Nanorods [J].DOSE-RESPONSE,2018,16(3).
APA：

Pan Su,Xing Hongcun,Fu Xuqi,Yu Hongmei,&Sun Wei.(2018).The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid-Coated Gold Nanorods .DOSE-RESPONSE,16(3).
MLA：

Pan Su, et al. "The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid-Coated Gold Nanorods" .DOSE-RESPONSE 16,3(2018).
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