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Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death 期刊论文 WOS高被引论文

编号：

869FC55E29A19AA95E918713A1CDA83A
作者：

Li, Changfeng(李长锋)#*^[1]Zhang, Ying(张莹)^[1]Liu, Jiao^[2]Kang, Rui^[3]Klionsky, Daniel J.^[4,5]Tang, Daolin(唐道林)*^[2,3]
语种：

英文
期刊：

AUTOPHAGY ISSN：1554-8627 2021 年 17 卷 4 期 (948 - 960) ; APR 3
收录：
关键词：

Antiviral drug autophagy CGAS DNA damage ferroptosis mitochondria POLG TFAM STING1 tumor therapy
摘要：

Pancreatic cancer tends to be highly resistant to current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates. Here, we report that zalcitabine, an antiviral drug for human immunodeficiency virus infection, can suppress the growth of primary and immortalized human pancreatic cancer cells through the induction of ferroptosis, an iron-dependent form of regulated cell death. Mechanically, this effect relies on zalcitabine-induced mitochondrial DNA stress, which activates the STING1/TMEM173-mediated DNA sensing pathway, leading to macroautophagy/autophagy-dependent ferroptotic cell death via lipid peroxidation, but not a type I interferon response. Consequently, the genetic and pharmacological inactivation of the autophagy-dependent ferroptosis pathway diminishes the anticancer effects of zalcitabine in cell culture and animal models. Together, these findings not only provide a new approach for pancreatic cancer therapy but also increase our understanding of the interplay between autophagy and DNA damage response in shaping cell death.
推荐引用方式
GB/T 7714：

Li Changfeng,Zhang Ying,Liu Jiao, et al. Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death [J].AUTOPHAGY,2021,17(4):948-960.
APA：

Li Changfeng,Zhang Ying,Liu Jiao,Kang Rui,&Tang Daolin.(2021).Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death .AUTOPHAGY,17(4):948-960.
MLA：

Li Changfeng, et al. "Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death" .AUTOPHAGY 17,4(2021):948-960.
入库时间：

4/13/2021 2:42:16 PM
更新时间：

4/13/2021 2:42:16 PM

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