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An InjectableHydrogel Foam Enables Mechanical Resilienceand Zero-Order Release of Growth Factors for Intervertebral Disc Repair 期刊论文

编号：

DA0A232B76969671DBE5C3356FAB7809
作者：

Han, Guoyong#^[1]Li, Chaoyuan^[2];Dou, Hao^[3];Qi, Dianpeng^[3];Yang, Bai^[1,4];Liu, Wanguo(柳万国)*^[2]Gu, Rui(顾锐)^[2]Li, Yunfeng*^[1,4]
语种：

英文
期刊：

NANO LETTERS ISSN：1530-6984 2026 年 ; 2026 AUG 7
收录：
关键词：

injectable hydrogel foams bubble structures mechanical resilience zero-orderrelease intervertebraldisc degeneration
摘要：

Intervertebral disc degeneration (IVDD) is a global challenge to cure effectively. Although current hydrogel-based therapies are promising, they often have difficulty of completely reversing IVDD progression. Herein, we report an injectable and growth factor-laden hydrogel foam (IHFs@GFs) for the treatment of IVDD. IHF is prepared from methylphenyltetrazine-modified hyaluronic acid (HA-MTZ), norbornene-modified gelatin (Gelatin-NB), and norbornene-modified cellulose nanofibers (CNF-NB). MTZ reacts with NB to release N-2, spontaneously generating numerous closed and spherical N-2 bubbles in hydrogels. These N-2 bubbles endow IHF with good mechanical resilience and pressure buffering. Moreover, IHF shows zero-order release of transforming growth factor-beta 3 and insulin-like growth factor-1. Notably, after 8 weeks of treatment with IHFs@GFs, the disc height and hydration in degenerated IVD are significantly restored to over 90%, thereby enabling effective treatment of IVDD. The IHF integrates biomechanics and zero-order release of biologics within a single system, offering a promising platform for IVDD treatment.
推荐引用方式
GB/T 7714：

Han Guoyong,Li Chaoyuan,Dou Hao, et al. An InjectableHydrogel Foam Enables Mechanical Resilienceand Zero-Order Release of Growth Factors for Intervertebral Disc Repair [J].NANO LETTERS,2026.
APA：

Han Guoyong,Li Chaoyuan,Dou Hao,Qi Dianpeng,&Li Yunfeng.(2026).An InjectableHydrogel Foam Enables Mechanical Resilienceand Zero-Order Release of Growth Factors for Intervertebral Disc Repair .NANO LETTERS.
MLA：

Han Guoyong, et al. "An InjectableHydrogel Foam Enables Mechanical Resilienceand Zero-Order Release of Growth Factors for Intervertebral Disc Repair" .NANO LETTERS(2026).
入库时间：

8/24/2026 9:36:26 PM
更新时间：

8/24/2026 9:36:26 PM

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